Complete avoidance may not be possible, provided sufficient time elapses between use of the drugs. Isosorbide mononitrate slow-release tablets or capsules: Isosorbide dinitrate slow-release tablets: Isosorbide dinitrate immediate release tablets: Taking too much isosorbide mononitrate or dinitrate may cause your blood pressure to fall too low, making you feel sick, faint and dizzy. Conversion table Original isosorbide prescription: Convert to: 10 mg twice a day at 8am and 4pm 20 mg twice a day at 8am and 4pm [2] Contact dermatitis occurs in up to 40% of patients using transdermal The most common side-effect is headache. Some people may be able to stop taking it after certain types of heart surgery. Readily (and almost completely) absorbed from the GI tract and oral mucosa, but considerable variations in the bioavailability (1090%) secondary to extensive first-pass metabolism in the liver. Your doctor may tell you to leave a gap of 4 to 12 hours a day (usually when you are sleeping) where you do not take the tablets or capsules. On the basis of V-HeFT I and II results, an application was filed with the Food and Drug Administration for a methods patent on the H-ISDN combination in 1987, 17 which would give marketing rights for the combination specifically for heart failure. Isosorbide dinitrate | Drugs | BNF | NICE The metabolism of this drug occurs in the liver, and the elimination half-life is about 5 hours. Keep taking your medicine until you have had your review. This activity will . Initially, (e.g., Imdur): 30 mg (as a single 30-mg tablet or as of a 60-mg tablet) or 60 mg (as a single 60-mg tablet) once daily. Isosorbide mononitrate has one nirate group and isosorbide dinatrate has 2 nitro groups. The organic nitrates are vasodilators, active on both arteries and veins. Talk to your doctor if you want to stop taking isosorbide mononitrate or dinitrate. The isosorbide mononitrate extended-release tablet is an oral extended-release formulation of ISMN, the major active metabolite of isosorbide dinitrate; most of the clinical activity of the dinitrate is attributable to the mononitrate. If you have darker skin your gums or the skin around your eyes may turn blue or grey these are signs of low oxygen levels in your body, your heart starts beating much faster or slower than usual, you get chest pain that is different or worse than your usual angina pain, you get severe pain in your eye, headache, blurred vision or you suddenly go blind in one eye these could be signs of acute angle closure glaucoma, you get a skin rash that may include itchy, red, swollen, blistered or peeling skin, your mouth, face, lips, tongue or throat start swelling, medicines for erection problems including, calcium channel blockers to relax the arteries, increasing blood supply to the heart muscle, build up your activity level gradually and take regular breaks, keep your GTN tablets or spray with you in case you need them, use your tablets or spray before starting exercise, if you need to.