; et al. Differences in the social consequences of ethanol emerge during the course of adolescence in rats: Social facilitation, social inhibition, and anxiolysis. Roles of dopamine 2 receptor isoforms and G proteins in ethanol regulated prolactin synthesis and lactotropic cell proliferation. PMID: 6316391, Sarkar, D. K.; Kuhn, P.; Marano, J.; et al. ; Emsley, R.A.; et al. Alcoholism: Clinical and Experimental Research 12(6):731734, 1988. 1997). However, more studies are needed to help with our understanding of the adipose tissue pathology associated with alcohol abuse. Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the International Journal of Psychophysiology 59(3):244250, 2006. AVP also may affect cognitive function, because treatment of alcoholic patients with memory deficits by using AVP analogs resulted in improved cognitive performance (Laczi 1987). Blood 96(5):17231732, 2000. 2003; Ehrenreich et al. 1999). Ethanol also increased plasma prolactin levels and pituitary weight both in female rats with normal menstrual cycles and in rats whose ovaries had been removed (i.e., ovariectomized rats) and promoted estradiol-induced development of prolactin-producing benign tumors (i.e., prolactinomas) in the pituitary (De et al. 11. This delay could be prevented by naltrexone, an antagonist of the opioid receptors (Emanuele et al. 2008; Wang et al. PMID: 3146228, McGregor, I.S., and Bowen, M.T. ADH is made in a part of the brain called the hypothalamus and stored in the pituitary gland, a small gland found in the base of the brain. It also appears vulnerable to damage from . 2000). Overdosing on alcohol often follows blackouts, which can be dangerous and even lethal. ; De Vries, G.J. ; Sliwowska, J.H. Excessive use of alcohol causes a variety of chemical and molecular alterations within the brain that forms the basis of several behavioral and physical manifestations. 2004). Thus without a properly functioning hippocampus learning and memory become problematic. Influence of ethanol on growth hormone secretion in adult and prepubertal female rats. This effect was associated with a significant decline in circulating IGF-1, LH, and estrogen and was most pronounced at 32 months of age. Inhibition of nitric oxide synthase prevents the alcohol-induced decrease in testosterone (Adams et al.